Relationship of Physical Activity and Polymorphism Angiotensin Converting Enzyme Insertion / Deletion with Hypertension Occurrence in Coastal Communities

Abstract

Hypertension is caused by various risk factors, including angiotensin converting enzyme insertion/deletion (ACE I/D) that plays a role in the pathogenesis of hypertension and physical activity that can influence the incidence of hypertension. This research aimed to determine the relationship of physical activity patterns and polymorphisms od the ACE gene I/D with the incidence of hypertension in coastal communities of Kendari City. This research is an observational analytic with experimental method, through molecular biology approach, and case control study design. The population is coastal community of Kendari city od Southeast Sulawesi Province, in the work area of Puskesmas Mata, Puskesmas Nambo and Puskesmas Abeli. The sample amount is 70 people consisting of 35 case samples and 35 control samples. Method of sampling is purposive sampling and using PCR instrument to assess Presence of ACE I/D gene polymorphism and International Physical Activity Questionnaire (IPAQ) to measure physical activity. Data analysis with ChiSquare statistic test with p value <0,050, and Hardy Weinberg to calculate allel frequency. The result of analysis indicated that there was a correlation between ACE I/D gene polymorphism and hypertension occurrence with OR 0,794 had no significant effect with p value 0,631 (>0,05). There was a significant relationship between polymorphism of ACE I/D gene and hypertension incidence, in coastal community of Kendari City.