Relationship between AIP with hs-CRP and ADMA on Type 2 Diabetes Mellitus

Abstract

The aim of this research is to know the correlation between Atherogenic Index of Plasma (AIP) with high sensitive C protein (hs-CRP) and Asimmetric Dimethylarginin (ADMA) in type 2 diabetes mellitus (T2DM). Diabetics proven to be more susceptible to atherosclerosis and coronary heart disease (CDH), especially in patients with T2DM have higher risk and mortality for cardiovascular risk factors. AIP is a strong marker to predict the risk of atherosclerosis and CHD. hs-CRP is an acute phase protein produced in the liver, the part of in the immune system response and in acute inflammatory conditions. ADMA is an inhibitor on Nitric Oxide-forming ensymes, may be used as a marker of endhotelial function. This research methode used cross sectional design. The sample of this research were 80 T2DM patient with inclusion requirement men, age 30-65 years old, fasting glucose ≥ 126 mg/dl, AIC ≥ 6% and willing to sign inform consent. The conclution that AIP and has-CRP increased in patients with T2DM (p < 0.001) and there was a significant relationship between AIP and hs-CPR (r = 0.486, p < 0.001). The AIP score was not correlated with ADMA in T2DM subjects (r = -0.007, p = 0.915).